Overview: Bupropion is used to treat depression, seasonal affective disorder (SAD), and to help you quit smoking. It works by regulating chemicals in your brain called norepinephrine and dopamine. Bupropion extended-release (SR), brand name Zyban, is an atypical antidepressant. It's taken by adults for smoking cessation (quitting smoking) only. It works by easing symptoms of nicotine withdrawal and lowering your cravings for nicotine. Zyban helps people stop smoking by reducing cravings and other withdrawal effects. Learn about side effects, interactions and indications. Wellbutrin SR and XL are available in generic form in the United States and Canada. In 1997, bupropion was approved by the FDA for use as a smoking cessation aid under the name Zyban. [191][189] In 2006, Wellbutrin XL was similarly approved as a treatment for seasonal affective disorder. [192][193] DESCRIPTION ZYBAN (bupropion hydrochloride) Sustained-Release Tablets are a non-nicotine aid to smoking cessation. ZYBAN is chemically unrelated to nicotine or other agents currently used in. Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mental/mood disorders, and smoking cessation. Antidepressants can help prevent suicidal thoughts/attempts and provide other important benefits. Zyban (Bupropion Hcl) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Learn the differences between Zyban vs Wellbutrin, including uses, effectiveness, and side effects to choose the best treatment for your needs. Bupropion is an antidepressant medication used to treat depression and seasonal affective disorder. It also supports smoking cessation and weight management. Bupropion is the active ingredient in Wellbutrin and Zyban, Auvelity contains bupropion and dextromethorphan, and Contrave contains bupropion and naltrexone. Zyban is a brand of bupropion, which is a medication that helps you quit smoking. It works by reducing cravings for nicotine.